Our lab focuses on developing methods to understand the relationshipe between sequence, structure, and function of genome and epigenome at the single-cell and single-molecule levels. Our efforts are split between building new tools to leverage the power of high-throughput sequencing and cutting-edge microscopies, and bringing these new technologies to bear against basic biological questions of genomic and epigenomic variation. Areas of investigation include:
We are located the Beckman Center for Genetic Medicine (2nd floor and basement).
Our paper with the Bustamante and Willerslev labs describing target enrichment methods for ancient DNA sequencing was just published online! Congrats to Jason and Meredith!
Our paper with the Chang lab describing ATAC-seq, a powerful and simple new method for probing open chromatin, nucleosomes, and factor binding in limited numbers of cells, has been published in Nature Methods! Congrats to Jason!
One postdoctoral postion available for those interested in integrative epignomic analysis (see our "Join Us" page for details).
Congrats to Lauren Chircus for winning "best poster" at the Chemical Systems Biology retreat!
One joint postdoctoral position (between the Greenleaf and Sherlock labs) is available! Please see our "Join Us" page for details.
The lab has received a grant from the Rita Allen Foundation to work on epigenomics of cancer. Read more here.
29 March, 2013
Congrats to Sarah Denny, Jason Buenrostro for both getting NSF Fellowships. Further congrats to rotation students Ian Winters, Alicia Schep, and Zach Zappala for also getting NSF Fellowships. Well done to all!
21 September, 2013
21 September, 2012
21 September, 2012
4 June, 2012
1 June, 2012
16 April, 2012
We are looking to populate the new lab!
Positions available for motivated and spirited graduate students, postdoctoral fellows, and undergraduates.