We are interested in uncovering the biophysical basis and evolutionary consequences of sequence-function relationships.
Linking the biophysical functional landscape to fitness
Using comprehensive biophysical datasets, we are able to reconstruct quantitative evolutionary functional landscapes that relate underlying DNA sequence changes to functional defects or improvements in encoded molecules. This mapping provides a detailed understanding of the biophysical constraints that molecular evolution operates upon, allowing a linkage between quantitative biochemical aspects of biological systems and evolutionary fitness.
Buenrostro JD*, Araya CL*, Chircus LM, Layton CJ, Chang HY, Snyder MP, and Greenleaf WJ. (2014) "Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes." Nature Biotechnology