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Greenleaf Lab

Laboratory of Experimental Digital Biology
Department of Genetics
Stanford University School of Medicine

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Publications

 

 

Men Y, Fu Y, Chen Z, Sims PA, Greenleaf WJ, and Huang Y. (2012) "Digitial polymerase chain reaction in an array of femtoliter polydimethylsiloxane microreactors." Analytical Chemistry in press

 

 

Fluorogenic Sequencing

Sims PA*, Greenleaf WJ*, Duan H, and Xie XS (2011) “Fluorogenic DNA sequencing in PDMS microreactors.” Nature Methods 8(7) 575-580

* Equal contribution

 

 

OTW

Gutierrez-Medina B, Andreasson JOL, Greenleaf WJ, La Porta A, and Block SM. (2010) “An optical apparatus for rotation and trapping.” Meth. Enzymol. 475:377-404

 

 

Riboswitch

Greenleaf WJ*, Frieda KL, Foster, DAN, Woodside MT*, and Block SM. (2008) “Direct observation of hierarchical folding in single riboswitch aptamers.” Science, 319:630-633.

* Equal contribution

 

 

 

Termination

Larson MH*, Greenleaf WJ*, Landick R, and Block SM. (2008) “Applied force reveals mechanistic and energetic details of transcription termination.” Cell, 132:971-982

*Equal contribution

 

 

 

MotionSequencing

Greenleaf WJ, and Block SM. (2006) “Single-molecule, motion-based DNA sequencing using RNA polymerase.” Science 313:801.

 

 

BaseStepping

Abbondanzieri EA*, Greenleaf WJ*, Shaevitz JW, Landick R, Block, SM (2005) “Direct observation of basepair stepping by RNA polymerase.” Nature. 438(7067):460-465.

 

 

ForceClamp

Greenleaf WJ*, Woodside MT*, Abbondanzieri EA, Block SM. (2005) “Passive all-optical force clamp for high resolution laser trapping.” Phys. Rev. Lett. 95:208102.

*Equal contribution

 

 

 

GoldWires

Marszalek PE, Greenleaf WJ, Li HB, Oberhauser AF, Fernandez JM. (2000) “Atomic force microscopy captures quantized plastic deformation in gold nanowires.” Proc. Natl. Acad. Sci. USA. 97 (12): 6282-6286.

 

 

AcousticTransfection

Greenleaf WJ, Bolander ME, Sarkar G, Goldring MB, Greenleaf JF. (1998). “Artificial cavitation nuclei significantly enhance acoustically induced cell transfection.” Ultrasound in Medicine and Biology. 24 (4): 587-595.

 

 

Reviews

 

RNAP Review

Herbert, KM, Greenleaf WJ, and Block SM. (2008) “Single molecule measurements of RNA polymerase: motoring along.” Ann. Rev. Biochem. 77: 149-176.

 

 

Single Molecule Review

Greenleaf WJ, Woodside MT, and Block SM. (2007) “High-resolution, single-molecule measurements of biomolecular motion.” Ann. Rev Biophys. Biomol. Struct. 36:171-90.

 
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